PTFEP–Al2O3 hybrid nanowires reducing thrombosis and biofouling

Ayman Haidar; Awadelkareem A. Ali; Salih Veziroglu; Jacek Fiutowski; Hermann Eichler; Isabelle Müller; Karin Kiefer; Franz Faupel; Markus Bischoff; Michael Veith; Oral Cenk Aktas; Hashim Abdul-Khaliq

doi:10.1039/C9NA00436J

PTFEP–Al₂O₃ hybrid nanowires reducing thrombosis and biofouling†

Ayman Haidar,^a Awadelkareem A. Ali,^a Salih Veziroglu,

^b Jacek Fiutowski,^c Hermann Eichler,^d Isabelle Müller,^d Karin Kiefer,^a Franz Faupel,

^b Markus Bischoff,^e Michael Veith,^f Oral Cenk Aktas

*^ab and Hashim Abdul-Khaliq*^a

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* Corresponding authors

^a Department of Paediatric Cardiology, Saarland University, Building 9, 66421 Homburg, Germany
E-mail: Hashim.Abdul-Khaliq@uks.eu

^b Chair for Multicomponent Materials, Institute for Materials Science, Faculty of Engineering, Christian-Albrechts-University of Kiel, Kaiserstr. 2, 24143 Kiel, Germany
E-mail: oca@tf.uni-kiel.de

^c Mads Clausen Institute, NanoSYD, University of Southern Denmark, Alsion 2, 6400 Sønderborg, Denmark

^d Institute of Clinical Hemostaseology and Transfusion Medicine, Saarland University, Building 1, Ringstr. 52, 66421 Homburg, Germany

^e Institute of Medical Microbiology and Hygiene, Saarland University, Homburg/Saar, Germany

^f INM-Leibniz Institute for New Materials, Campus D2 2, Saarbrücken, Germany

Abstract

Thrombosis and bacterial infection are major problems in cardiovascular implants. Here we demonstrated that a superhydrophobic surface composed of poly(bis(2,2,2-trifluoroethoxy)phosphazene) (PTFEP)–Al₂O₃ hybrid nanowires (NWs) is effective to reduce both platelet adhesion/activation and bacterial adherence/colonization. The proposed approach allows surface modification of cardiovascular implants which have 3D complex geometries.

Nanoscale Advances

PTFEP–Al₂O₃ hybrid nanowires reducing thrombosis and biofouling†

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PTFEP–Al₂O₃ hybrid nanowires reducing thrombosis and biofouling

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