Issue 32, 2019

Synthesis of novel isoindole-containing phakellistatin 2 analogs and the conformation features affecting their antitumor activities

Abstract

Two novel isoindole-doped cyclopeptide analogs of phakellistatin 2 with γ-turns were prepared. The compound with all D-Pro residues showed better antitumor activity against HepG-2 cells than that containing all L-Pro moieties, indicating the importance of the handedness of the conformation. LDH release tests showed that the compounds killed the cancer cells through a membrane disruption mechanism.

Graphical abstract: Synthesis of novel isoindole-containing phakellistatin 2 analogs and the conformation features affecting their antitumor activities

Supplementary files

Article information

Article type
Paper
Submitted
10 Apr 2019
Accepted
10 Jul 2019
First published
11 Jul 2019

New J. Chem., 2019,43, 12609-12613

Synthesis of novel isoindole-containing phakellistatin 2 analogs and the conformation features affecting their antitumor activities

L. Zhao, J. Wu, Y. Bao, S. Jiang, Z. Wang, C. Guo, Y. Jin and F. Qu, New J. Chem., 2019, 43, 12609 DOI: 10.1039/C9NJ01832H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements