Issue 31, 2019

Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery

Abstract

The anticancer drug 6-MP was covalently bonded to the –OH group of poly(HPMA) via a glutathione-responsive carbonyl vinyl sulfide linker. In vitro simulation assay demonstrated that the poly(HPMA)–PTA conjugate exhibited a markedly enhanced antitumor effect on HepG2 cells.

Graphical abstract: Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery

Supplementary files

Article information

Article type
Letter
Submitted
19 May 2019
Accepted
05 Jul 2019
First published
10 Jul 2019

New J. Chem., 2019,43, 12215-12220

Glutathione responsive poly(HPMA) conjugate nanoparticles for efficient 6-MP delivery

W. Xu, G. Li, H. Long, G. Fu and L. Pu, New J. Chem., 2019, 43, 12215 DOI: 10.1039/C9NJ02582K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements