The properties of the sonochemically functionalized nonsteroidal anti-inflammatory drug ketorolac in an Fe3O4–graphene oxide nanocomposite

Abstract

Metallodrugs are in clinical use for the treatment of some diseases. A feasible sonochemical method is described for the complexation of the nonsteroidal anti-inflammatory drug, ketorolac, with an Fe₃O₄–graphene oxide nanocomposite. The extraction of ketorolac from this nanocomposite was studied in aqueous solutions at pH = 1, 5 and 8, imitating the gastrointestinal medium.