Issue 13, 2019

Non-invasive isolation of rare circulating tumor cells with a DNA mimic of double-sided tape using multimeric aptamers

Abstract

Circulating tumor cells (CTCs) are indicative for cancer diagnosis and prognosis. However, conventional immuno-magnetic cell capture technologies using antibody- and aptamer-functionalized magnetic particles generate increased intracellular oxidative stress through endocytosis. Herein, we efficiently, selectively, and non-invasively isolate CTCs from whole blood by mimicking double-sided tape using DNA.

Graphical abstract: Non-invasive isolation of rare circulating tumor cells with a DNA mimic of double-sided tape using multimeric aptamers

Supplementary files

Article information

Article type
Communication
Submitted
12 Jan 2019
Accepted
04 Mar 2019
First published
07 Mar 2019

Nanoscale, 2019,11, 5879-5883

Non-invasive isolation of rare circulating tumor cells with a DNA mimic of double-sided tape using multimeric aptamers

Y. Chen, W. Wang, D. Tyagi, A. J. Carrier, S. Cui, S. He and X. Zhang, Nanoscale, 2019, 11, 5879 DOI: 10.1039/C9NR00364A

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