Issue 16, 2019

Assisting anti-PD-1 antibody treatment with a liposomal system capable of recruiting immune cells

Abstract

Despite the functions of anti-PD-1 antibodies as immune checkpoint regulators, less than 30% of patients exhibit durable therapeutic responses to anti-PD-1 antibodies. Studies have shown that insufficient infiltration of immune cells might limit the outcome of anti-PD-1 therapy. Therefore, we synthesized an immune cell-recruiting liposomal system (FN-nps) to improve this therapeutic strategy. The FN-nps could generate cell debris and expose heat shock protein 70, which could recruit immune cells to tumor sites to assist in anti-PD-1 treatment. In vivo experiments revealed that the FN-nps could assist in anti-PD-1 therapy by increasing the number of lymphocytes in the peripheral blood and tumor site by generating tumor antigens, and this effect was accompanied by an increase in cytokine expression. The number of CTLs increased and mRNA expression levels of cytokines were regulated when the FN-nps were combined with anti-PD-1 therapy. The revealed properties of the liposomal system make it highly promising for assisting in anti-PD-1 antibody immunotherapy in different cancers.

Graphical abstract: Assisting anti-PD-1 antibody treatment with a liposomal system capable of recruiting immune cells

Supplementary files

Article information

Article type
Paper
Submitted
16 Feb 2019
Accepted
28 Mar 2019
First published
29 Mar 2019

Nanoscale, 2019,11, 7996-8011

Assisting anti-PD-1 antibody treatment with a liposomal system capable of recruiting immune cells

B. Zhou, Q. Jiang, X. Xiao, X. Xu, Y. Xu, Y. Kong, W. Zhang, Y. Zeng, X. Liu and B. Luo, Nanoscale, 2019, 11, 7996 DOI: 10.1039/C9NR01434A

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