Biodegradable MnO2 nanosheet mediated hybridization chain reaction for imaging of human apurinic/apyrimidinic endonuclease 1 activity in living cells

Guangli Li; Junjie Li; Qing Li

doi:10.1039/C9NR06436B

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Biodegradable MnO₂ nanosheet mediated hybridization chain reaction for imaging of human apurinic/apyrimidinic endonuclease 1 activity in living cells†

Guangli Li,^a Junjie Li^b and Qing Li

*^a

Author affiliations

* Corresponding authors

^a Hunan Key Laboratory of Biomedical Nanomaterials and Devices, College of Life Science and Chemistry, Hunan University of Technology, Zhuzhou 412007, P. R. China
E-mail: qingli@hut.edu.cn
Fax: +86-731-22183793
Tel: +86-731-22183793

^b State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China

Abstract

A highly sensitive enzyme-free amplification assay for the detection of apurinic/apyrimidinic endonuclease 1 activity was developed. By incorporating biodegradable MnO₂ nanosheets, in situ light up intracellular APE 1 activity was achieved.

Download options Please wait...

Supplementary files

Supplementary information PDF (1542K)

Article information

DOI: https://doi.org/10.1039/C9NR06436B
Article type: Communication
Submitted: 28 Jul 2019
Accepted: 07 Oct 2019
First published: 08 Oct 2019

Download Citation

Nanoscale, 2019,11, 20456-20460

Permissions

Request permissions

Biodegradable MnO₂ nanosheet mediated hybridization chain reaction for imaging of human apurinic/apyrimidinic endonuclease 1 activity in living cells

G. Li, J. Li and Q. Li, Nanoscale, 2019, 11, 20456 DOI: 10.1039/C9NR06436B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Nanoscale