A modular approach for cytosolic protein delivery: metal ion-induced self-assembly of gold nanoclusters as a general platform

Lirui Wang; Chunlei Zhang; Tianliang Li; Meng Duan; Fangfang Xia; Xinhong Li; Cunfeng Song; Shaojun Pan; Bin Liu; Daxiang Cui

doi:10.1039/C9NR07334E

A modular approach for cytosolic protein delivery: metal ion-induced self-assembly of gold nanoclusters as a general platform†

Lirui Wang,^a Chunlei Zhang,

*^ab Tianliang Li,^a Meng Duan,^a Fangfang Xia,^a Xinhong Li,^c Cunfeng Song,^a Shaojun Pan,^a Bin Liu^a and Daxiang Cui

*^ab

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* Corresponding authors

^a Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China
E-mail: chunleizhang@sjtu.edu.cn, dxcui@sjtu.edu.cn

^b National Center for Translational Medicine, Collaborative Innovational Center for System Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China

^c Shanghai Key Lab of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, PR China

Abstract

We developed a versatile and modular method for cytosolic protein delivery through metal ion-induced co-assembly of gold nanoclusters and proteins into supramolecular assemblies. The versatility and high efficiency of this strategy to assemble and deliver various proteins into living cells were demonstrated. Importantly, the activity of proteins was maintained during the delivery. This modular approach provides an exciting and promising new nano-platform for cytosolic protein delivery.

Nanoscale

A modular approach for cytosolic protein delivery: metal ion-induced self-assembly of gold nanoclusters as a general platform†

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A modular approach for cytosolic protein delivery: metal ion-induced self-assembly of gold nanoclusters as a general platform

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