Issue 46, 2019
From the journal:

Nanoscale

2D DNA lattice arrays assembled from DNA dumbbell tiles using poly(A-T)-rich stems†

Mashooq Ali,a   Noshin Afshan,b   Chuan Jiang,a   Hongning Zhengc  and  Shou-Jun Xiao ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, Jiangsu, China
E-mail: sjxiao@nju.edu.cn

b Institute of Molecular Medicine, Renji Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai 200001, China

c Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, China

Abstract

Poly(A-T)-rich sequences have been applied as stems of DNA dumbbell tiles for construction of single crystalline 2D DNA lattice arrays in slightly acidic solutions. These arrays show much higher stability and better organised crystalline lattice structures than those assembled from DNA dumbbell tiles with randomly sequenced stems in slightly alkaline environments. DNA nanotechnology probably provides a useful platform to study the mechanical properties of DNA duplexes with specific sequences.

Graphical abstract: 2D DNA lattice arrays assembled from DNA dumbbell tiles using poly(A-T)-rich stems

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Article information

DOI
https://doi.org/10.1039/C9NR07911D
Article type
Communication
Submitted
14 Sep 2019
Accepted
30 Oct 2019
First published
31 Oct 2019

Nanoscale, 2019,11, 22216-22221

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2D DNA lattice arrays assembled from DNA dumbbell tiles using poly(A-T)-rich stems

M. Ali, N. Afshan, C. Jiang, H. Zheng and S. Xiao, Nanoscale, 2019, 11, 22216 DOI: 10.1039/C9NR07911D

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