HAP-01, the first chromogenic substrate for Aspergillus oryzae acid protease

Taku Yoshiya; Nobuo Yamashita; Shugo Tsuda; Koushou Oohigashi; Shun Masuda; Takafumi Kubodera; Takahito Akashi

doi:10.1039/C8OB02766H

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HAP-01, the first chromogenic substrate for Aspergillus oryzae acid protease†

Taku Yoshiya,

*^a Nobuo Yamashita,

^b Shugo Tsuda,

^a Koushou Oohigashi,^b Shun Masuda,^a Takafumi Kubodera^b and Takahito Akashi^b

Author affiliations

* Corresponding authors

^a Peptide Institute, Inc., Ibaraki, Osaka 567-0085, Japan
E-mail: t.yoshiya@peptide.co.jp
Web: https://www.peptide.co.jp/en

^b Research Department, Hakutsuru Sake Brewing Co. Ltd., Kobe, Hyogo 658-0041, Japan
Web: http://www.hakutsuru.co.jp/english/

Abstract

The first chromogenic substrate for Aspergillus oryzae acid protease, ‘HAP-01’, was successfully developed after evaluating the substrate specificity of the enzyme. Furthermore, with HAP-01, digestion-triggered chromophore release was employed as a novel chromogenic technique.

This article is part of the themed collection: Chemical Biology in OBC

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Article information

DOI: https://doi.org/10.1039/C8OB02766H
Article type: Communication
Submitted: 07 Nov 2018
Accepted: 19 Dec 2018
First published: 20 Dec 2018

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Org. Biomol. Chem., 2019,17, 776-779

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HAP-01, the first chromogenic substrate for Aspergillus oryzae acid protease

T. Yoshiya, N. Yamashita, S. Tsuda, K. Oohigashi, S. Masuda, T. Kubodera and T. Akashi, Org. Biomol. Chem., 2019, 17, 776 DOI: 10.1039/C8OB02766H

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Organic & Biomolecular Chemistry

HAP-01, the first chromogenic substrate for Aspergillus oryzae acid protease†

Abstract

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HAP-01, the first chromogenic substrate for Aspergillus oryzae acid protease

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