Base-promoted direct synthesis of functionalized N-arylindoles via the cascade reactions of allenic ketones with indoles

Abstract

A convenient Cs₂CO₃-promoted cascade benzannulation reaction of allenic ketones with indoles was achieved for the synthesis of functionalized N-arylindole derivatives under transition-metal-free conditions. A series of readily available starting materials can undergo the process successfully. It represents a practical method for the construction of N-arylindole scaffolds with high atom economy.