Issue 17, 2019

A facile one pot synthesis of thiazolo[3,2-a]benzimidazole and pyran fused polyheterocyclic scaffolds

Abstract

An efficient synthesis of dihydro-4H-benzo[4,5]imidazo[2,1-b]pyrano[2,3-d]thiazole by a multicomponent route starting from 2-((1H-benzo[d]imidazol-2-yl)thio)-1-phenylethan-1-one, an aromatic aldehyde and malononitrile is described. This protocol features a metal free approach with good substrate scope and decent yield. The heterocyclic skeleton obtained in this study may have interesting biological properties.

Graphical abstract: A facile one pot synthesis of thiazolo[3,2-a]benzimidazole and pyran fused polyheterocyclic scaffolds

Supplementary files

Article information

Article type
Communication
Submitted
07 Feb 2019
Accepted
25 Mar 2019
First published
25 Mar 2019

Org. Biomol. Chem., 2019,17, 4196-4199

A facile one pot synthesis of thiazolo[3,2-a]benzimidazole and pyran fused polyheterocyclic scaffolds

A. Mariappan, K. Rajaguru, S. Muthusubramanian and N. Bhuvanesh, Org. Biomol. Chem., 2019, 17, 4196 DOI: 10.1039/C9OB00300B

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