Issue 20, 2019

Fluorination-triggered tandem cyclization of styrene-type carboxylic acids to access 3-aryl isocoumarin derivatives under microwave irradiation

Abstract

A practical and straightforward synthetic route through a fluorination-triggered tandem cyclization of styrene-type carboxylic acids was developed to construct a variety of 4-fluoro-3-aryl-3,4-dihydroisocoumarins and 3-arylisocoumarins under microwave irradiation. This novel protocol features mild reaction conditions and operational simplicity, with good yields.

Graphical abstract: Fluorination-triggered tandem cyclization of styrene-type carboxylic acids to access 3-aryl isocoumarin derivatives under microwave irradiation

Supplementary files

Article information

Article type
Paper
Submitted
01 Mar 2019
Accepted
24 Apr 2019
First published
24 Apr 2019

Org. Biomol. Chem., 2019,17, 5038-5046

Fluorination-triggered tandem cyclization of styrene-type carboxylic acids to access 3-aryl isocoumarin derivatives under microwave irradiation

J. Yuan, F. Zeng, W. Mai, L. Yang, Y. Xiao, P. Mao and D. Wei, Org. Biomol. Chem., 2019, 17, 5038 DOI: 10.1039/C9OB00509A

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