Cobalt-catalyzed cyclization with the introduction of cyano, acyl and aminoalkyl groups†
Abstract
An efficient synthesis of carbo- and heterocycles using CC, CO and CN bonds under cobalt catalysis is described. The substituents on olefins are key for controlling the regio- and chemoselectivity in the initial hydrogen atom transfer step and quaternary carbons are efficiently constructed under mild conditions. Cyclopropane cleavage and tandem cyclization give highly functionalized bicyclic skeletons in a single operation.
- This article is part of the themed collection: Synthetic methodology in OBC