Issue 21, 2019

The base-free van Leusen reaction of cyclic imines on water: synthesis of N-fused imidazo 6,11-dihydro β-carboline derivatives

Abstract

Construction of imidazoles has been demonstrated on water under base-free conditions. The reaction of dihydro β-carboline imines and p-toluenesulfonylmethyl isocyanides furnished the corresponding substituted N-fused imidazo 6,11-dihydro β-carboline derivatives in very good yields under ambient conditions. The use of deuterium oxide (D2O) as a solvent enabled the incorporation of deuterium isotopes in the imidazole ring.

Graphical abstract: The base-free van Leusen reaction of cyclic imines on water: synthesis of N-fused imidazo 6,11-dihydro β-carboline derivatives

Supplementary files

Article information

Article type
Communication
Submitted
21 Mar 2019
Accepted
01 May 2019
First published
01 May 2019

Org. Biomol. Chem., 2019,17, 5234-5238

The base-free van Leusen reaction of cyclic imines on water: synthesis of N-fused imidazo 6,11-dihydro β-carboline derivatives

K. Satyam, V. Murugesh and S. Suresh, Org. Biomol. Chem., 2019, 17, 5234 DOI: 10.1039/C9OB00660E

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