Issue 23, 2019

Chemical synthesis of the dimeric repeating unit of type Ia group B Streptococcus capsular polysaccharide

Abstract

The first chemical synthesis of the dimeric repeating unit of serotype Ia group B Streptococcus capsular polysaccharide was achieved. The on-site elongation and dual glycosylation strategies were utilized to construct two sialotrisaccharide branches based on a hexasaccharide containing adjacent 3,4-di-branched Gal units, which were synthesized via a preactivation-based one-pot glycosylation method.

Graphical abstract: Chemical synthesis of the dimeric repeating unit of type Ia group B Streptococcus capsular polysaccharide

Supplementary files

Article information

Article type
Paper
Submitted
04 May 2019
Accepted
23 May 2019
First published
24 May 2019

Org. Biomol. Chem., 2019,17, 5839-5848

Chemical synthesis of the dimeric repeating unit of type Ia group B Streptococcus capsular polysaccharide

H. Zhang, S. Zhou, Y. Zhao and J. Gao, Org. Biomol. Chem., 2019, 17, 5839 DOI: 10.1039/C9OB01024F

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