Issue 27, 2019

Organocatalytic asymmetric synthesis of dihydrofuran-spirooxindoles from benzylidene malononitriles and dioxindoles

Abstract

The first organocatalytic enantioselective synthesis of dihydrofuran-spirooxindoles having a linkage at the 2-position of the dihydrofuran motif has been developed. Dioxindoles and benzylidene malononitriles were employed in this method. The desired spirooxindole products were obtained via a Michael reaction followed by a Pinner reaction and isomerization and good to high yields with moderate diastereo and good to high enantioselectivities were observed.

Graphical abstract: Organocatalytic asymmetric synthesis of dihydrofuran-spirooxindoles from benzylidene malononitriles and dioxindoles

Supplementary files

Article information

Article type
Communication
Submitted
22 May 2019
Accepted
18 Jun 2019
First published
18 Jun 2019

Org. Biomol. Chem., 2019,17, 6557-6561

Organocatalytic asymmetric synthesis of dihydrofuran-spirooxindoles from benzylidene malononitriles and dioxindoles

M. Balha, B. Mondal and S. C. Pan, Org. Biomol. Chem., 2019, 17, 6557 DOI: 10.1039/C9OB01199D

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