Silver-promoted decarboxylative radical addition/annulation of oxamic acids with gem-difluoroolefins: concise access to CF2-containing 3,4-dihydroquinolin-2-ones†
Peijun
Liu 
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and
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and
Abstract
Described is a silver-promoted decarboxylative radical addition/annulation of oxamic acids with gem-difluoroalkenes. This reaction proceeded under mild reaction conditions with broad functional group compatibility, enabling the convenient synthesis of various structurally diverse CF2-containing 3,4-dihydroquinolin-2-ones that might find applications in medical chemistry.
- This article is part of the themed collections: Synthetic methodology in OBC and Catalysis & biocatalysis in OBC
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