Issue 28, 2019
From the journal:

Organic & Biomolecular Chemistry

Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging†

Shota Yanagi,a   Tomoya Sugai,b   Takuma Noguchi,a   Masato Kawakami,a   Makoto Sasaki,a   Shinsuke Niwa,c   Asako Sugimotoa  and  Haruhiko Fuwa ORCID logo *b  

* Corresponding authors

a Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan

b Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan
E-mail: hfuwa.50m@g.chuo-u.ac.jp

c Frontier Research Institute for Interdisciplinary Sciences (FRIS), Tohoku University, 6-3 Aramaki Aoba, Aoba-ku, Sendai, Miyagi 980-0845, Japan

Abstract

Design, synthesis and functional analysis of fluorescent derivatives of neopeltolide, an antiproliferative marine macrolide, are reported herein. Live cell imaging using the fluorescent derivatives showed rapid cellular uptake and localization within the endoplasmic reticulum as well as the mitochondria.

Graphical abstract: Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging

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Article information

DOI
https://doi.org/10.1039/C9OB01276A
Article type
Communication
Submitted
03 Jun 2019
Accepted
24 Jun 2019
First published
25 Jun 2019

Org. Biomol. Chem., 2019,17, 6771-6776

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Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging

S. Yanagi, T. Sugai, T. Noguchi, M. Kawakami, M. Sasaki, S. Niwa, A. Sugimoto and H. Fuwa, Org. Biomol. Chem., 2019, 17, 6771 DOI: 10.1039/C9OB01276A

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