Double-stranded oligodeoxyribonucleotides with +1 interstrand zipper arrangements of 2′-O-(pyren-1-yl)methyl-RNA monomers are additionally activated for highly specific recognition of mixed-sequence DNA targets upon incorporation of non-nucleotidic spermine bulges.
S. P. Adhikari, R. G. Emehiser, S. Karmakar and P. J. Hrdlicka, Org. Biomol. Chem., 2019, 17, 8795 DOI: 10.1039/C9OB01686D
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