Functionalization of activated methylene C–H bonds with nitroarenes and sulfur for the synthesis of thioamides

Abstract

We report a method to obtain arylthioamides by the functionalization of sp³ C–H bonds in phenylacetic acids and benzyl alcohols. Reactions proceeded without the use of any solvents and were compatible with many functionalities and heterocycles. These conditions allow for a rapid synthesis of thioamides from simple, commercial substrates.