Rhizophols A and B, antioxidant and axially chiral benzophenones from the endophytic fungus Cytospora rhizophorae

Abstract

Two novel polyketones, rhizophols A–B (1–2), were isolated from the endophytic fungus Cytospora rhizophorae A761. They shared unprecedented poly-substituted benzophenone skeletons featuring an epoxy isopentyl unit and a propionyl moiety. Their structures were evidenced by extensive spectroscopic analyses, X-ray diffraction, and quantum energy calculation. Moreover, compound 1 was proved to be a promising lead compound for novel antioxidant drugs.