Issue 2, 2019

Synthesis, photochemical and in vitro cytotoxic evaluation of benzoselenazole-based aminosquaraines

Abstract

Squaraine dyes have recently attracted interest as potential second generation photosensitizers for photodynamic therapy. Several cationic aminosquaraine dyes bearing benzoselenazole terminal nuclei were synthezised and their cytotoxic activity was tested against four different human tumor cell lines – breast (MCF-7), non-small cell lung (NCI-H460), cervical (HeLa) and hepatocellular (HepG2) carcinomas – and against a non-tumor porcine liver primary cell line (PLP2), both in the absence of light and under irradiation. All dyes, which displayed strong absorption within the phototherapeutic window, were found to exhibit photodynamic activity and were shown to be, in most cases, more cytotoxic, both in the dark and upon irradiation, than their benzothiazole analogues.

Graphical abstract: Synthesis, photochemical and in vitro cytotoxic evaluation of benzoselenazole-based aminosquaraines

Article information

Article type
Paper
Submitted
10 May 2018
Accepted
19 Sep 2018
First published
24 Sep 2018

Photochem. Photobiol. Sci., 2019,18, 336-342

Synthesis, photochemical and in vitro cytotoxic evaluation of benzoselenazole-based aminosquaraines

Á. F. Magalhães, V. C. Graça, R. C. Calhelha, I. L. Ferreira Machado, L. F. Vieira Ferreira, I. C. F. R. Ferreira and P. F. Santos, Photochem. Photobiol. Sci., 2019, 18, 336 DOI: 10.1039/C8PP00201K

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