Issue 2, 2019

In situ intravenous photodynamic therapy for the systemic eradication of blood stream infections

Abstract

Photodynamic therapy is one of the most promising non-invasive strategies employed for the treatment of several kinds of bacterial infections. Though the vast majority of clinically approved photosensitisers are administered intravenously, most of the in vitro experiments are performed under static conditions which do not represent the physiological environment of the venous bloodstream. To address this issue, a dynamic circulation model was developed to facilitate in situ antibacterial photodynamic therapy under flow conditions to mimic blood stream infections.

Graphical abstract: In situ intravenous photodynamic therapy for the systemic eradication of blood stream infections

Article information

Article type
Communication
Submitted
25 Jun 2018
Accepted
18 Dec 2018
First published
20 Dec 2018

Photochem. Photobiol. Sci., 2019,18, 304-308

In situ intravenous photodynamic therapy for the systemic eradication of blood stream infections

M. Raschpichler, M. R. Agel, S. R. Pinnapireddy, L. Duse, E. Baghdan, J. Schäfer and U. Bakowsky, Photochem. Photobiol. Sci., 2019, 18, 304 DOI: 10.1039/C8PP00267C

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