Interaction of pH-responsive polyanions with phospholipid membranes

Edit Brodszkij; Martin J. Hviid; Carina Ade; Philipp S. Schattling; Moritz Burmeister; Sven Szilagyi; Noga Gal; Chuntao Zhu; Xiaojun Han; Brigitte Städler

doi:10.1039/C9PY00924H

Interaction of pH-responsive polyanions with phospholipid membranes†

Edit Brodszkij,

^a Martin J. Hviid,^a Carina Ade,^a Philipp S. Schattling,^a Moritz Burmeister,^a Sven Szilagyi,^a Noga Gal,

^a Chuntao Zhu,^ab Xiaojun Han

^b and Brigitte Städler

*^a

Author affiliations

* Corresponding authors

^a Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus, Denmark
E-mail: bstadler@inano.au.dk

^b State Key Laboratory of Urban Water Resource and Environment School of Chemistry and Chemical Engineering, Harbin Institute of Technology, 92 West Da-Zhi Street, Harbin, China

Abstract

The behavior of two acrylate polymers, with carboxylic acid side groups, was investigated with regard to their pH-responsive interaction with phospholipid membranes. The polyanions crossed the membrane of giant unilamellar vesicles and mammalian cells with low cytotoxicity in the latter case.

Polymer Chemistry

Interaction of pH-responsive polyanions with phospholipid membranes†

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