Issue 7, 2019

Diazido platinum(iv) complexes for photoactivated anticancer chemotherapy

Abstract

Diazido Pt(IV) complexes with a general formula [Pt(N3)2(L)(L′)(OR)(OR′)] are a new generation of anticancer prodrugs designed for use in photoactivated chemotherapy. The potencies of these complexes are affected by the cis/trans geometry configuration, the non-leaving ligand L/L′ and derivatisation of the axial ligand OR/OR′. Diazido Pt(IV) complexes exhibit high dark stability and promising photocytotoxicity circumventing cisplatin resistance. Upon irradiation, diazido Pt(IV) complexes release anticancer active Pt(II) species, azidyl radicals and ROS, which interact with biomolecules and therefore affect the cellular components and pathways. The conjugation of diazido Pt(IV) complexes with anticancer drugs or cancer-targeting vectors is an effective strategy to optimise the design of these photoactive prodrugs. Diazido Pt(IV) complexes represent a series of promising anticancer prodrugs owing to their novel mechanism of action which differs from that of classical cisplatin and its analogues.

Graphical abstract: Diazido platinum(iv) complexes for photoactivated anticancer chemotherapy

Article information

Article type
Review Article
Submitted
15 Mar 2019
Accepted
26 Apr 2019
First published
30 May 2019
This article is Open Access
Creative Commons BY license

Inorg. Chem. Front., 2019,6, 1623-1638

Diazido platinum(IV) complexes for photoactivated anticancer chemotherapy

H. Shi, C. Imberti and P. J. Sadler, Inorg. Chem. Front., 2019, 6, 1623 DOI: 10.1039/C9QI00288J

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