Issue 1, 2019

Unprecedented thiocarbamidation of nitroarenes: a facile one-pot route to unsymmetrical thioureas

Abstract

Aromatic nitro compounds undergo one-pot thiocarbamide functionalization upon reacting with in situ generated dithiocarbamate anions in the presence of K2CO3 and DMF solvent to produce unsymmetrical thiourea compounds in good yields. Various cyclic and acyclic 2° amines, 1° amines, and aromatic amines reacted with CS2 to form dithiocarbamate anions which combine with different nitroarenes resulting in the formation of thiourea compounds. The reaction is assumed to proceed through a nitrosobenzene intermediate.

Graphical abstract: Unprecedented thiocarbamidation of nitroarenes: a facile one-pot route to unsymmetrical thioureas

Supplementary files

Article information

Article type
Research Article
Submitted
23 Jul 2018
Accepted
16 Nov 2018
First published
19 Nov 2018

Org. Chem. Front., 2019,6, 70-74

Unprecedented thiocarbamidation of nitroarenes: a facile one-pot route to unsymmetrical thioureas

S. Dutta, M. Mondal, T. Ghosh and A. Saha, Org. Chem. Front., 2019, 6, 70 DOI: 10.1039/C8QO00752G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements