Issue 5, 2019

Cytorhizophins A and B, benzophenone-hemiterpene adducts from the endophytic fungus Cytospora rhizophorae

Abstract

A pair of novel enantiomeric benzophenone-hemiterpene adducts, (+)-cytorhizophin A (1a) and (−)-cytorhizophin A (1b) as well as cytorhizophin B (2), all of them featuring an unprecedented 6/7/6/7 tetracyclic fused ring system, together with their biosynthetically related precursor cytorhizophin C (3) were isolated from Cytospora rhizophorae A761. Their structures were fully characterized on the basis of extensive spectroscopic analysis, with the absolute configurations of 1 determined by X-ray diffraction and electronic circular dichroism (ECD) calculations. Moreover, compounds 1–3 were evaluated for in vitro antimicrobial activity.

Graphical abstract: Cytorhizophins A and B, benzophenone-hemiterpene adducts from the endophytic fungus Cytospora rhizophorae

Supplementary files

Article information

Article type
Research Article
Submitted
05 Dec 2018
Accepted
14 Jan 2019
First published
15 Jan 2019

Org. Chem. Front., 2019,6, 591-596

Cytorhizophins A and B, benzophenone-hemiterpene adducts from the endophytic fungus Cytospora rhizophorae

H. Liu, H. Tan, W. Wang, W. Zhang, Y. Chen, S. Li, Z. Liu, H. Li and W. Zhang, Org. Chem. Front., 2019, 6, 591 DOI: 10.1039/C8QO01306C

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