Issue 7, 2019

Highly efficient copper-catalyzed direct C–H amidation of quinoxalin-2(1H)-ones with amidates under microwave irradiation

Abstract

A novel and highly efficient copper-catalyzed direct oxidative amidation of quinoxalin-2(1H)-ones with a variety of aromatic and aliphatic amides was described. This methodology provided a practical approach to various 3-acylamino quinoxalin-2(1H)-ones from readily available starting materials in good to excellent yields.

Graphical abstract: Highly efficient copper-catalyzed direct C–H amidation of quinoxalin-2(1H)-ones with amidates under microwave irradiation

Supplementary files

Article information

Article type
Research Article
Submitted
15 Jan 2019
Accepted
08 Feb 2019
First published
12 Feb 2019

Org. Chem. Front., 2019,6, 925-935

Highly efficient copper-catalyzed direct C–H amidation of quinoxalin-2(1H)-ones with amidates under microwave irradiation

J. Yuan, J. Zhu, J. Fu, L. Yang, Y. Xiao, P. Mao, X. Du and L. Qu, Org. Chem. Front., 2019, 6, 925 DOI: 10.1039/C9QO00063A

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