Issue 9, 2019

Catalyst-free oxidative N–N coupling for the synthesis of 1,2,3-triazole compounds with tBuONO

Abstract

We disclose a catalyst-free method to synthesize 1,2,3-triazoles rapidly via an oxidative N–N coupling strategy. Of particular note is that the one-step synthesis route to access [1,2,3]triazolo[1,5-a]pyridines from pyridin-2-ylmethanamine has been reported for the first time. This approach features no use of catalyst, extremely mild conditions and excellent efficiency.

Graphical abstract: Catalyst-free oxidative N–N coupling for the synthesis of 1,2,3-triazole compounds with tBuONO

Supplementary files

Article information

Article type
Research Article
Submitted
16 Jan 2019
Accepted
17 Mar 2019
First published
19 Mar 2019

Org. Chem. Front., 2019,6, 1481-1484

Catalyst-free oxidative N–N coupling for the synthesis of 1,2,3-triazole compounds with tBuONO

Y. Cai, X. Zhang, C. An, Y. Yang, W. Liu, W. Gao, X. Huang, Y. Zhou, M. Liu and H. Wu, Org. Chem. Front., 2019, 6, 1481 DOI: 10.1039/C9QO00071B

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