Nickel-catalyzed C–H bond trifluoromethylation of 8-aminoquinoline derivatives by acyl-directed functionalization

Abstract

A Ni(TFA)₂-catalyzed ortho-trifluoromethylation of 8-aminoquinoline derivatives was developed by acyl-directed C–H functionalization. A series of 7-trifluoromethylquinolinamine derivatives were originally obtained with moderate to excellent yields by using TMSCF₃ as the trifluoromethylation reagent under mild conditions. In addition, the reaction mechanism is proposed and proved by the related experiment.