A one-pot protocol for the synthesis of β-ketosulfones from α,α-dibromoketones

Abstract

A one-pot debromination/sulfonylation strategy was developed for the direct transformation of α,α-dibromoketones into β-ketosulfones in the presence of sulfinate salts in a methanol solution. A broad range of α,α-dibromoketones react smoothly with various aryl/alkyl sulfinates under neutral and catalyst-free conditions, affording diverse β-ketosulfones in good to excellent yields. The plausible mechanism was studied.