Issue 18, 2019

Pd-Catalyzed intramolecular C–H activation and C–S formation to synthesize pyrazolo[5,1-b]benzothiazoles without an additional oxidant

Abstract

Herein, an efficient synthesis of pyrazolo[5,1-b]benzothiazole scaffold via Pd-catalyzed intramolecular C–H activation and C–S formation was reported. By starting from easily available 1-phenyl-1H-pyrazole-5-thiol compounds, a series of substituted pyrazolo[5,1-b]benzothiazoles were obtained with moderate to good yields. Interestingly, this reaction didn't need any additional oxidant and the reaction conditions were also suitable for the synthesis of imidazo[2,1-b]benzothiazole derivatives.

Graphical abstract: Pd-Catalyzed intramolecular C–H activation and C–S formation to synthesize pyrazolo[5,1-b]benzothiazoles without an additional oxidant

Supplementary files

Article information

Article type
Research Article
Submitted
06 Apr 2019
Accepted
26 Jul 2019
First published
30 Jul 2019

Org. Chem. Front., 2019,6, 3234-3237

Pd-Catalyzed intramolecular C–H activation and C–S formation to synthesize pyrazolo[5,1-b]benzothiazoles without an additional oxidant

Y. Peng, Q. He, X. Zhang and C. Yang, Org. Chem. Front., 2019, 6, 3234 DOI: 10.1039/C9QO00484J

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