Transition-metal-free N-difluoromethylation of hydrazones with TMSCF2Br as the difluoromethylation reagent

Abstract

Herein a novel and practical protocol to synthesize a series of N-difluoromethyl hydrazones via base-promoted N-difluoromethylation is reported. With hydrazones as chain substrates containing N–N bonds and TMSCF₂Br as the difluoromethylation reagent, the reaction delivers N-difluoromethyl hydrazones in good yields, which exhibit good functional group tolerance and stereoselectivity.