DMF/NaOH/H2O: a metal-free system for efficient and chemoselective reduction of α-ketoamides

Rongcong Ye; Feiyue Hao; Guyue Liu; Qingsong Zuo; Lijun Deng; Zhengneng Jin; Jiashou Wu

doi:10.1039/C9QO00842J

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

DMF/NaOH/H₂O: a metal-free system for efficient and chemoselective reduction of α-ketoamides†

Rongcong Ye,^a Feiyue Hao,^a Guyue Liu,^a Qingsong Zuo,^a Lijun Deng,^a Zhengneng Jin^a and Jiashou Wu

*^a

Author affiliations

* Corresponding authors

^a School of Pharmaceutical and Materials Engineering, Taizhou University, Taizhou 318000, Zhejiang, P. R. China
E-mail: jsw79@tzc.edu.cn

Abstract

We have developed a transition metal free method for efficient and chemoselective reduction of C [double bond, length as m-dash] O bonds using DMF as a hydrogen source and solvent. α-Ketoamides bearing various functional groups are smoothly reduced to α-hydroxyamides in high yields with the present DMF/NaOH/H₂O reduction system.

Download options Please wait...

Supplementary files

Supplementary information PDF (4337K)

Article information

DOI: https://doi.org/10.1039/C9QO00842J
Article type: Research Article
Submitted: 02 Jul 2019
Accepted: 03 Sep 2019
First published: 04 Sep 2019

Download Citation

Org. Chem. Front., 2019,6, 3562-3565

Permissions

Request permissions

DMF/NaOH/H₂O: a metal-free system for efficient and chemoselective reduction of α-ketoamides

R. Ye, F. Hao, G. Liu, Q. Zuo, L. Deng, Z. Jin and J. Wu, Org. Chem. Front., 2019, 6, 3562 DOI: 10.1039/C9QO00842J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic Chemistry Frontiers