Synthesis of α-trifluoromethyl ethanone oximes via the three-component reaction of aryl-substituted ethylenes, tert-butyl nitrite, and the Langlois reagent

Abstract

A mild and simple protocol for the synthesis of α-trifluoromethylated ethanone oximes from aryl-substituted ethylenes, tert-butyl nitrite, and the Langlois reagent was developed under transition metal-free conditions. In this three-component reaction, tert-butyl nitrite was employed not only as the oxidant but also as the oxime source. A range of α-trifluoromethylated ethanone oximes were obtained, indicating the wide substrate scope of the reaction.