Issue 22, 2019

Celamonols A–D, four triterpenoid and catechin conjugates with immunosuppressive activities from the stems of Celastrus monospermus

Abstract

Celamonols A–D (1–4), featuring an unusual pattern of conjunction between a 24,29-dinorfriedelane-type triterpenoid and a catechin, were isolated from the stems of Celastrus monospermus. Their structures were elucidated by extensive spectroscopic analyses, modified Mosher's method, and ECD calculations. Compounds 1 and 4 exhibited moderate activities against the proliferation of B lymphocytes with IC50 values of 1.46 and 1.35 μM, respectively.

Graphical abstract: Celamonols A–D, four triterpenoid and catechin conjugates with immunosuppressive activities from the stems of Celastrus monospermus

Supplementary files

Article information

Article type
Research Article
Submitted
03 Aug 2019
Accepted
08 Oct 2019
First published
10 Oct 2019

Org. Chem. Front., 2019,6, 3786-3792

Celamonols A–D, four triterpenoid and catechin conjugates with immunosuppressive activities from the stems of Celastrus monospermus

J. Qin, Y. Fu, X. Chen, Y. Liu, J. Zhao, J. Zuo, Y. Li, W. Zhu and W. Zhao, Org. Chem. Front., 2019, 6, 3786 DOI: 10.1039/C9QO00974D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements