Issue 23, 2019

Synthesis of 1-naphthols via Cp*Co(iii)-catalyzed C–H activation and cyclization of sulfoxonium ylides with alkynes

Abstract

A highly practical and efficient synthesis of 1-naphthols was developed via Cp*Co(III)-catalyzed C–H activation and cascade [4 + 2] cyclization between sulfoxonium ylides and alkynes, during which the sulfoxonium ylide functioned as a traceless directing group. This method features operational simplicity, redox-neutral reaction conditions, excellent regioselectivity and good substrate compatibility, and various 1-naphthols were efficiently synthesized in 36–92% yields.

Graphical abstract: Synthesis of 1-naphthols via Cp*Co(iii)-catalyzed C–H activation and cyclization of sulfoxonium ylides with alkynes

Supplementary files

Article information

Article type
Research Article
Submitted
12 Aug 2019
Accepted
11 Oct 2019
First published
12 Oct 2019

Org. Chem. Front., 2019,6, 3868-3873

Synthesis of 1-naphthols via Cp*Co(III)-catalyzed C–H activation and cyclization of sulfoxonium ylides with alkynes

Y. Yu, Q. Wu, D. Liu, L. Yu, Z. Tan and G. Zhu, Org. Chem. Front., 2019, 6, 3868 DOI: 10.1039/C9QO00994A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements