Issue 23, 2019

Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition

Abstract

Commiphorines A (1), an unprecedented sesquiterpenoid heterodimer featuring a 5/7(5)/4/10/5 ring system, and B (2), a dimeric sesquiterpenoid possessing an unusual 1,4-dioxin motif and a 6/6/5/6/6/6 polycyclic system, and two intermediates 3 and 4 were isolated from Resina Commiphora. A plausible biosynthetic route for 1 and 2 was proposed. Compound 2 could significantly suppress LPS-induced inflammation through NF-κB and MAPK signaling pathways in mouse peritoneal macrophages. Compounds 1 and 2 could inhibit lipid synthesis in HepG2 cells.

Graphical abstract: Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition

Supplementary files

Article information

Article type
Research Article
Submitted
24 Aug 2019
Accepted
07 Oct 2019
First published
09 Oct 2019

Org. Chem. Front., 2019,6, 3825-3833

Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition

L. Dong, D. Qin, Q. Di, Y. Liu, W. Chen, S. Wang and Y. Cheng, Org. Chem. Front., 2019, 6, 3825 DOI: 10.1039/C9QO01046G

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