Issue 12, 2019, Issue in Progress
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RSC Advances

Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe†

Ying Ma,a   Haigang Tian,a   Zhengyu Jin,a   Xiaoyong Lib  and  Yiping Li ORCID logo *a  

* Corresponding authors

a School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China
E-mail: yipingli@mail.xjtu.edu.cn

b School of Science, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China
E-mail: lixy6658@mail.xjtu.edu.cn

Abstract

A ratiometric fluorescent probe, BTPB, for the selective monitoring of hepatic peroxynitrite (ONOO−) in situ after acetaminophen (APAP) overdose has been developed. Our study provided direct evidence for supporting the generation of ONOO− in APAP-induced liver injury. This new probe will be a useful tool for studying the roles of ONOO− in vivo.

Graphical abstract: Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe

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Article information

DOI
https://doi.org/10.1039/C8RA10053E
Article type
Paper
Submitted
06 Dec 2018
Accepted
15 Feb 2019
First published
25 Feb 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 6510-6514

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Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe

Y. Ma, H. Tian, Z. Jin, X. Li and Y. Li, RSC Adv., 2019, 9, 6510 DOI: 10.1039/C8RA10053E

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