Issue 19, 2019
From the journal:

RSC Advances

Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C–H bonds utilizing amino acids as a directing group†

Zhanqing Cong,‡abc   Feng Gao‡ab  and  Hong Liu ORCID logo *abc  

* Corresponding authors

a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, China
E-mail: hliu@simm.ac.cn

b University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China

c School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China

Abstract

The nickel(II)-catalyzed ortho-arylation of unactivated C–H bonds utilizing amino acids as directing groups with aryl iodides or bromides as coupling electrophiles is described. This protocol features excellent mono-selectivity, good regioselectivity, and wide functional group tolerance. Additionally, the obtained products bearing a biaryl motif and an amino acid represent bioactive molecules with wide bioactivities.

Graphical abstract: Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C–H bonds utilizing amino acids as a directing group

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Article information

DOI
https://doi.org/10.1039/C9RA00749K
Article type
Paper
Submitted
28 Jan 2019
Accepted
27 Mar 2019
First published
08 Apr 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 10820-10824

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Ni(II)-catalyzed mono-selective ortho-arylation of unactivated aryl C–H bonds utilizing amino acids as a directing group

Z. Cong, F. Gao and H. Liu, RSC Adv., 2019, 9, 10820 DOI: 10.1039/C9RA00749K

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