Issue 12, 2019
From the journal:

RSC Advances

Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles†

Alexander V. Aksenov, ORCID logo *a   Vladislav Khamraev, ORCID logo a   Nicolai A. Aksenov, ORCID logo a   Nikita K. Kirilov,a   Dmitriy A. Domenyuk,b   Vladimir A. Zelenskyb  and  Michael Rubin ORCID logo *ac  

* Corresponding authors

a Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355009, Russian Federation
E-mail: alexaks05@rambler.ru

b Department of General Practice Dentistry and Child Dentistry, Stavropol State Medical University, 310 Mira Street, Stavropol 355017, Russian Federation

c Department of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS 66045-7582, USA
E-mail: mrubin@ku.edu
Tel: +1-785-864-5071

Abstract

A novel methodology for general and chemoselective preparation of non-symmetric 1,3,4-oxadiazoles is developed. This unusual reaction proceeds via polyphosphoric acid-assisted activation of nitroalkanes towards nucleophilic attack with acylhydrazides.

Graphical abstract: Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles

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Article information

DOI
https://doi.org/10.1039/C9RA00976K
Article type
Paper
Submitted
05 Feb 2019
Accepted
12 Feb 2019
First published
26 Feb 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 6636-6642

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Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles

Alexander V. Aksenov, V. Khamraev, N. A. Aksenov, N. K. Kirilov, D. A. Domenyuk, V. A. Zelensky and M. Rubin, RSC Adv., 2019, 9, 6636 DOI: 10.1039/C9RA00976K

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