Issue 35, 2019, Issue in Progress
From the journal:

RSC Advances

Microwave-assisted organic synthesis of nucleoside ProTide analogues†

Cinzia Bordoni,a   Cecilia Maria Cima,a   Elisa Azzali,b   Gabriele Costantinob  and  Andrea Brancale ORCID logo *a  

* Corresponding authors

a School of Pharmacy and Pharmaceutical Sciences, Redwood Building, King Edward VII Avenue, Cardiff, UK
E-mail: brancalea@cardiff.ac.uk

b P4T Group, Dipartimento di Farmacia, University of Parma, Parco Area delle Scienze 27/A, Parma, Italy

Abstract

A microwave enhanced synthesis of prodrug nucleotide (ProTide) analogues is presented. Comparison of conventional thermal heating reaction with microwave irradiation exemplifies the potential of the novel methodology herein presented for the selective 5′-phosphoramidate synthesis, without protection of the 3′ position in the ribonucleoside.

Graphical abstract: Microwave-assisted organic synthesis of nucleoside ProTide analogues

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Article information

DOI
https://doi.org/10.1039/C9RA01754B
Article type
Paper
Submitted
07 Mar 2019
Accepted
19 Jun 2019
First published
27 Jun 2019
This article is Open Access
Creative Commons BY license

RSC Adv., 2019,9, 20113-20117

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Microwave-assisted organic synthesis of nucleoside ProTide analogues

C. Bordoni, C. M. Cima, E. Azzali, G. Costantino and A. Brancale, RSC Adv., 2019, 9, 20113 DOI: 10.1039/C9RA01754B

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