Issue 27, 2019, Issue in Progress
From the journal:

RSC Advances

Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose†

Alessandra Locatelli,‡a   Luisa Iommarini,‡a   Alessandra Graziadio,a   Alberto Leoni,a   Anna Maria Porcelli,ab   Stefano Iotti, ORCID logo ac   Emil Malucelli,a   Francesco Francia,a   Giovanni Venturolia  and  Giovanna Farruggia ORCID logo ‡*ac  

* Corresponding authors

a Dipartimento di Farmacia e Biotecnologie (FABIT), Università degli Studi di Bologna, Bologna, Italy
E-mail: Giovanna.Farruggia@unibo.it

b Centro Interdipartimentale di Ricerca Industriale (CIRI) Scienze della Vita e Tecnologie per la Salute, Università di Bologna, 40100 Bologna, Italy

c National Institute of Biostructures and Biosystems, Roma 00136, Italy

Abstract

A fluorescent derivative of trehalose with two dansyl groups (DAT) has been synthesized. It is characterised by a large Stokes shift, good permeability in human living cells and a well detectable fluorescent signal within the cells. Notably, in intestinal cells DAT is sequestered in vesicles induced by trehalose pre-treatment and colocalizes with lipid droplets.

Graphical abstract: Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose

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Article information

DOI
https://doi.org/10.1039/C9RA01800J
Article type
Paper
Submitted
09 Mar 2019
Accepted
19 Apr 2019
First published
16 May 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 15350-15356

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Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose

A. Locatelli, L. Iommarini, A. Graziadio, A. Leoni, A. M. Porcelli, S. Iotti, E. Malucelli, F. Francia, G. Venturoli and G. Farruggia, RSC Adv., 2019, 9, 15350 DOI: 10.1039/C9RA01800J

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