15N labeling and analysis of 13C–15N and 1H–15N couplings in studies of the structures and chemical transformations of nitrogen heterocycles

Abstract

This review provides a generalization of effective examples of ¹⁵N labeling followed by an analysis of ¹³C–¹⁵N (J_CN) and ¹H–¹⁵N (J_HN) coupling constants in solution as a tool to study the structural aspects and pathways of chemical transformations (e.g., rearrangements and ring-chain tautomerisms) in monocyclic and fused nitrogen heterocycles. This approach allows us to significantly expand and supplement the scope of NMR techniques for heterocyclic compounds. Moreover, methods for the incorporation of ¹⁵N atoms into the cores of various N-heterocycles have been collected in this work.