UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng

Hailin Zhu; Junli Liu; Hongqiang Lin; Ying Zhang; Na Yang; Baisong Zhou; Zhongyao Wang; Alan Chen-Yu Hsu; Jinping Liu; Pingya Li

doi:10.1039/C9RA06635G

UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng†

Hailin Zhu,^a Junli Liu,^a Hongqiang Lin,^a Ying Zhang,^ac Na Yang,^a Baisong Zhou,^a Zhongyao Wang,^a Alan Chen-Yu Hsu,^d Jinping Liu

*^ab and Pingya Li*^a

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* Corresponding authors

^a School of Pharmaceutical Sciences, Jilin University, Fujin Road 1266, Changchun 130021, Jilin, China
E-mail: liujp@jlu.edu.cn, lipy@jlu.edu.cn
Tel: +86-431-85619803

^b Research Center of Natural Drug, Jilin University, Changchun 130021, Jilin, China

^c The First Hospital of Jilin University, Changchun 130021, Jilin, China

^d Priority Research Centre for Healthy Lungs, Faculty of Health and Medicine, The University of Newcastle, Newcastle, NSW, Australia

Abstract

Four previously undescribed ginsenosides, along with five known analogues were isolated from wild ginseng by a UPLC-QTOF-MS-guided fractionation procedure. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, HR-ESI-MS). The isolated compounds could significantly inhibit the cigarette smoke extract (CSE)-induced inflammatory reaction in A549 cells. The HDAC2 pathway might be involved in the protective effect against the CSE-mediated inflammatory response in A549 cells.

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UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng†

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UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng

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