Issue 60, 2019

Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites

Abstract

The revolutionary discovery of penicillin only marks the start of our exploration for valuable fungal natural products. Advanced genome sequencing technologies have translated the fungal genome into a huge reservoir of “recipes” – biosynthetic gene clusters (BGCs) – for biosynthesis. Studying complex fungal genetics demands specific gene manipulation strategies. This review summarizes the current progress in efficient gene targeting in fungal cells and heterologous expression systems for expressing fungal BGCs of fungal secondary metabolites.

Graphical abstract: Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites

Article information

Article type
Review Article
Submitted
30 Aug 2019
Accepted
18 Oct 2019
First published
30 Oct 2019
This article is Open Access
Creative Commons BY license

RSC Adv., 2019,9, 35124-35134

Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites

Y. Qiao, R. Yu and P. Zhu, RSC Adv., 2019, 9, 35124 DOI: 10.1039/C9RA06908A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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