Issue 68, 2019

Microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes

Abstract

An efficient and practical procedure was developed to prepare 7-azaindole, starting from an o-haloaromatic amine and corresponding terminal alkynes under microwave irradiation and the scope was demonstrated with a number of examples. The valuable features of this procedure included the iron-catalyzed cyclization, short reaction times and convenient operation. Furthermore, iron catalysis is an interesting alternative to homogeneous catalysis for the synthesis of heterocycles.

Graphical abstract: Microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes

Supplementary files

Article information

Article type
Paper
Submitted
24 Oct 2019
Accepted
26 Nov 2019
First published
02 Dec 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 39684-39688

Microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes

Y. Le, Z. Yang, Y. Chen, D. Chen, L. Yan, Z. Wang and G. Ouyang, RSC Adv., 2019, 9, 39684 DOI: 10.1039/C9RA08742G

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