Issue 66, 2019
From the journal:

RSC Advances

Excited-state locked amino analogues of the green fluorescent protein chromophore with a giant Stokes shift†

Snizhana O. Zaitseva,a   Dilara A. Farkhutdinova,b   Nadezhda S. Baleeva,a   Alexander Yu. Smirnov, ORCID logo a   Marina B. Zagudaylova,a   Aleksander M. Shakhov,c   Artyom A. Astafiev,cb   Mikhail S. Baranov*ad  and  Anastasia V. Bochenkova ORCID logo *b  

* Corresponding authors

a Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia
E-mail: baranovmikes@gmail.com

b Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1/3, 119991 Moscow, Russia
E-mail: bochenkova@phys.chem.msu.ru

c Semenov Institute of Chemical Physics of RAS, Moscow, Russia

d Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997, Russia

Abstract

We design a novel class of excited-state locked GFP chromophores by introducing an amine group at the double exo-bond and a difluoroboryl bridge. We show that these chromophores intrinsically exhibit a very large Stokes shift of 1 eV. Further tuning through chemical modifications of their aryl substituents makes them environmentally sensitive.

Graphical abstract: Excited-state locked amino analogues of the green fluorescent protein chromophore with a giant Stokes shift

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Article information

DOI
https://doi.org/10.1039/C9RA08808C
Article type
Paper
Submitted
15 Sep 2019
Accepted
18 Nov 2019
First published
26 Nov 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 38730-38734

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Excited-state locked amino analogues of the green fluorescent protein chromophore with a giant Stokes shift

S. O. Zaitseva, D. A. Farkhutdinova, N. S. Baleeva, A. Yu. Smirnov, M. B. Zagudaylova, A. M. Shakhov, A. A. Astafiev, M. S. Baranov and A. V. Bochenkova, RSC Adv., 2019, 9, 38730 DOI: 10.1039/C9RA08808C

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