Issue 72, 2019, Issue in Progress

Boron trifluoride etherate promoted microwave-assisted synthesis of antimalarial acridones

Abstract

A microwave-assisted, rapid and efficient method using boron trifluoride etherate (BF3.Et2O) for the synthesis of acridones, via an intramolecular acylation of N-phenylanthranilic acid derivatives, has been developed. The reaction proceeds under solvent-free conditions, tolerates a wide range of functional groups, and provides rapid access to a range of acridones in good to excellent yields. Several of the synthesized acridones exhibited potent antimalarial activities against CQ sensitive and multi-drug resistant (MDR) parasites.

Graphical abstract: Boron trifluoride etherate promoted microwave-assisted synthesis of antimalarial acridones

Supplementary files

Article information

Article type
Paper
Submitted
13 Nov 2019
Accepted
10 Dec 2019
First published
20 Dec 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 42284-42293

Boron trifluoride etherate promoted microwave-assisted synthesis of antimalarial acridones

P. Kancharla, R. A. Dodean, Y. Li and J. X. Kelly, RSC Adv., 2019, 9, 42284 DOI: 10.1039/C9RA09478D

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